We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relationship of fluoride in drinking water with blood pressure and essential hypertension prevalence: a systematic review and meta-analysis.
- Authors
Davoudi, Mojtaba; Barjasteh-Askari, Fateme; Sarmadi, Mohammad; Ghorbani, Mohammad; Yaseri, Mehdi; Bazrafshan, Edris; Mahvi, Amir Hossein; Moohebati, Mohsen
- Abstract
Background and objective: Previous studies showed controversial results of the relationship between fluoride exposure through drinking water and elevated blood pressure. We conducted a systematic review and meta-analysis to assess the direct relationship of drinking water fluoride exposure with blood pressure and essential hypertension prevalence in general populations. Methods: We conducted a systematic search in databases including Web of Knowledge, PubMed, Scopus, and Embase by MeSH and non-MeSH terms for relevant studies with any design published until August 2019, with no limitation in time and language. The pooled effect measure was calculated within a 95% confidence interval (CI). Results: Our search retrieved 630 journal articles, six of which were eligible for data extraction. The random-effects model found significantly higher systolic blood pressure (mean difference = 6.49 mmHg; 95% CI 3.73–9.25; p value < 0.01) and diastolic blood pressure (mean difference = 4.33 mmHg; 95% CI 1.39–7.26; p value < 0.01) in groups exposed to high-fluoride drinking water than in groups exposed to normal/low-fluoride drinking water. A significant relationship was also found between high-fluoride drinking water and essential hypertension (odds ratio = 2.14; 95% CI 1.02–4.49; p value = 0.045). Conclusion: The risk of elevated blood pressure increases in the general population of fluoride endemic areas. However, more research is needed to make a firm conclusion about the adverse effects of excess fluoride intake on the cardiovascular system at the individual level.
- Subjects
BLOOD pressure; ESSENTIAL hypertension; WATER pressure; SYSTOLIC blood pressure; FLUORIDES; DRINKING water; FLUORIDE varnishes
- Publication
International Archives of Occupational & Environmental Health, 2021, Vol 94, Issue 6, p1137
- ISSN
0340-0131
- Publication type
Article
- DOI
10.1007/s00420-021-01714-x