We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Local delivery of [sup 131]I-MIBG to treat peritoneal neuroblastoma.
- Authors
Kinuya, Seigo; Xiao-Feng Li; Yokoyama, Kunihiko; Mori, Hirofumi; Shiba, Kazuhiro; Watanabe, Naoto; Shuke, Noriyuki; Bunko, Hisashi; Michigishi, Takatoshi; Tonami, Norihisa
- Abstract
Internal radiotherapy involving systemic administration of iodine- 131 metaiodohenzylguanidine (131I-MIBG) in neural crest tumours such as neuroblastoma has shown considerable success. Although peritoneal seeding of neuroblastoma occurs less often than metastases to organs such as the liver, no effective treatments exist in this clinical setting. Previous reports have demonstrated the effectiveness of peritoneal application of chemotherapeutic drugs or radiolabelled monoclonal antibodies in several kinds of carcinomas. Local delivery of 131I-MIBG should produce more favourable dosimetry in comparison with its systemic administration in the treatment of peritoneal neuroblastoma. In the current investigation, a peritoneal model of neuroblastoma was established in Balh/c nu/nu mice by i.p. injection of SK-N- SH neuroblastoma cells. Two weeks after cell inoculation, comparative bio-distribution studies were performed following i.v. or i.p. administration of 131I-MIBG. Mice were treated with 55.5 MBq of 131I-MIBG administered either i.v. or i.p. at 2 weeks. Intraperitoneal injection of 131I-MIBG produced significantly higher tumour accumulation than did i.v. injection (P<0.01). Therapeutic ratios of i.p. injection were 4- to 14-fold higher than those of i.v. injection. Radiotherapy with i.v. administered 131I-MIBG failed to improve the survival of mice; mean survival of untreated mice and mice treated with i.v. administration of 131I-MIBG was 59.3±3.9 days and 60.6±2.8 days, respectively. On the other hand, radiotherapy delivered via i.p. administration of 131I-MIBG prolonged survival of mice to 94.7±17.5 days (P<0.02 vs untreated controls and mice treated with i.v. 131I-MIBG therapy). Radiation doses absorbed by tumours at 55.5 MBq of 131I-MIBG were estimated to he 4,140 cGy with i.p. injection and 450 cGy with i.v. injection. These results indicate the benefits of locoregional delivery of 131I-MIBG in the treatment of peritoneal neuroblastoma.
- Subjects
NEUROBLASTOMA; NERVOUS system tumors; SARCOMA; TUMORS; LIVER; IMMUNOGLOBULINS; DRUG dosage
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2003, Vol 30, Issue 9, p1246
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-003-1214-1