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- Title
drexplorer: A tool to explore dose-response relationships and drug-drug interactions.
- Authors
Pan Tong; Coombes, Kevin R.; Johnson, Faye M.; Byers, Lauren A.; Diao, Lixia; Liu, Diane D.; Lee, J. Jack; Heymach, John V.; Jing Wang
- Abstract
Motivation: Nonlinear dose-response models are primary tools for estimating the potency [e.g. half-maximum inhibitory concentration (IC) known as IC50] of anti-cancer drugs. We present drexplorer software, which enables biologists to evaluate replicate reproducibility, detect outlier data points, fit different models, select the best model, estimate IC values at different percentiles and assess drug-drug interactions. drexplorer serves as a computation engine within the R environment and a graphical interface for users who do not have programming backgrounds.
- Subjects
GENETIC databases; DATA mining; DRUG interactions
- Publication
Bioinformatics, 2015, Vol 31, Issue 10, p1692
- ISSN
1367-4803
- Publication type
Product Review
- DOI
10.1093/bioinformatics/btv028