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- Title
The Role of Polymorphisms Near the IL28B Gene on Response to Peg- Interferon and Ribavirin in Thalassemic Patients With Hepatitis C.
- Authors
Behnava, Bita; Sharafi, Heidar; Mehrnoush, Leila; Salimi, Shima; Elizee, Pegah Karimi; Pouryasin, Ali; Keshvari, Maryam; Ghazimoghaddam, Mehran
- Abstract
Background: Hepatitis C Virus (HCV) is the major cause of liver failure in thalassemic patients. In these patients, iron overload and their comorbidities make difficulties during Pegylated-Interferon (PEG-IFN) and Ribavirin (RBV) therapy. Objectives: We aimed to assess the impact of polymorphisms near the IL28B gene on virological response in HCV - infected thalassemic patients, who were treated with PEG-IFN and RBV. Patients and Methods: This cross - sectional study was conducted on 143 thalassemic patients with chronic hepatitis C, who were treated with a combination of PEG-IFN and RBV regimen. The RS12979860 and RS8099917 polymorphisms were assessed as the most common polymorphisms near the IL28B gene by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The rate of sustained virological response (SVR) was significantly lower in thalassemic patients with HCV genotype-1 infection compared to patients with HCV genotype-3 infection. Among baseline predictors, RS12979860 and RS8099917 polymorphisms were found to be the only parameters associated with achievement of SVR in thalassemic patients with HCV genotype-1 infection however, there was no association between these polymorphisms and the rate of SVR in thalassemic patients with HCV genotype-3 infection. Conclusions: In HCV genotype-1- infected thalassemic patients with RS12979860 CC genotype and without severe comorbidities, PEG-IFN and RBV combination therapy can be tried yet in those with RS12979860 CT/TT it may be reasonable to treat cases with new direct-acting antivirals.
- Publication
Hepatitis Monthly, 2016, Vol 16, Issue 1, p1
- ISSN
1735-143X
- Publication type
Article
- DOI
10.5812/hepatmon.32703