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- Title
超高效液相色谱-串联质谱法同时测定化妆品中 29种抗过敏药物.
- Authors
郑佳新; 贾昌平; 张珊珊
- Abstract
The study aims to develop an ultra high performance liquid chromatography-tandem mass spectrometry method for the determination of 29 anti-allergy drugs in cosmetics. The samples were extracted by ultrasonic machine with acetonitrile, and the separation was executed on a column using the mobile phase consisting of 0.1% ammonium hydroxide( A) and 0.1% ammonium hydroxide methanol solution( B). The analysis was performed using a positive electrospray ion source in multiple reaction monitoring( MRM) mode. The result show that the linear relationship of the 29 anti-allergy drugs in the linear range is good, and the correlation coefficient is greater than 0.997. The detection limits are between 0.4-12.9 ng/g, and the average recovery rate is in the range of 80.9%-115.9%, with RSD within 0.3%-14.8%. 2 Batches of positive samples are detected within 10 batches of the samples, cyproheptadine and cyproheptadine impurity 1 are found in 1 batch, and cimetidine is found in 1 batch. The established method is simple, selective, sensitive and accurate, and can be used for the determination of anti-allergy drugs in cosmetics.
- Subjects
LIQUID chromatography-mass spectrometry; ANTIALLERGIC agents; ULTRASONIC machining; AMMONIUM hydroxide; CATIONS
- Publication
China Surfactant Detergent & Cosmetics, 2023, Vol 53, Issue 7, p833
- ISSN
1001-1803
- Publication type
Article
- DOI
10.3969/j.issn.2097-2806.2023.07.014