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- Title
The impact of RAS mutation on the treatment strategy of colorectal cancer.
- Authors
Pirvu, Edvina Elena; Severin, Emilia; Niță, Irina; Toma, Ştefania Andreea
- Abstract
Kirsten rat sarcoma (KRAS) is the most frequently mutated oncogene in colorectal cancer, being present in 30% of patients with localized disease and in almost half of the patients that develop metastatic disease. While the development of chemotherapy doublets and targeted therapy have improved survival in recent years, KRAS mutation still has a controversial role regarding its prognostic and predictive value both in the adjuvant and in the metastatic setting. The impact of KRAS mutation on treatment strategy remains to be better defined. The development of new KRAS inhibitors promising new treatment options is on the horizon.
- Subjects
COLORECTAL cancer; RAS oncogenes; PROGNOSIS; ONCOGENES
- Publication
Medicine & Pharmacy Reports: Clujul Medical, 2023, Vol 96, Issue 1, p5
- ISSN
2602-0807
- Publication type
Article
- DOI
10.15386/mpr-2408