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- Title
Toxicity and Genotoxicity of Three Antimicrobials Commonly Used in Veterinary Medicine.
- Authors
Magdaleno, Anahí; Carusso, Sofía; Moretton, Juan
- Abstract
The toxicity of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) was tested on two green algal species: the international standard Pseudokirchneriella subcapitata and the native Argentine species Ankistrodesmus fusiformis. All three antibiotics inhibited the algal growth. The most sensitive species was P. subcapitata, for which the EC for CTC, OTC and ENF were 1.19 ± 0.53, 0.92 ± 0.30 and 5.18 ± 3.80 mg L, respectively. The EC for A. fusiformis, were 3.23 ± 0.53, 7.15 ± 2.69 and 10.6 ± 1.28 mg L, respectively. The genotoxicity of these veterinary antibiotics was also assessed using chromosome aberration (CA) and micronuclei (MN) induction in Allium cepa roots. Three concentrations were tested (0.1, 1 and 10 mg L). Only ENF at 1 and 10 mg L showed any significant MN induction. These data revealed that CTC, OTC and ENF could cause toxicity on green algae, whereas ENF could cause genotoxicity on A. cepa plants.
- Subjects
VETERINARY medicine; ANTI-infective agents; GENETIC toxicology; OXYTETRACYCLINE; FLUOROQUINOLONES; ANKISTRODESMUS
- Publication
Bulletin of Environmental Contamination & Toxicology, 2017, Vol 99, Issue 3, p315
- ISSN
0007-4861
- Publication type
Article
- DOI
10.1007/s00128-017-2091-9