We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A single-dose of intranasal vaccination with a live-attenuated SARS-CoV-2 vaccine candidate promotes protective mucosal and systemic immunity.
- Authors
Adam, Awadalkareem; Kalveram, Birte; Chen, John Yun-Chung; Yeung, Jason; Rodriguez, Leslie; Singh, Ankita; Shi, Pei-Yong; Xie, Xuping; Wang, Tian
- Abstract
An attenuated SARS-CoV-2 virus with modified viral transcriptional regulatory sequences and deletion of open-reading frames 3, 6, 7 and 8 (∆3678) was previously reported to protect hamsters from SARS-CoV-2 infection and transmission. Here we report that a single-dose intranasal vaccination of ∆3678 protects K18-hACE2 mice from wild-type or variant SARS-CoV-2 challenge. Compared with wild-type virus infection, the ∆3678 vaccination induces equivalent or higher levels of lung and systemic T cell, B cell, IgA, and IgG responses. The results suggest ∆3678 as an attractive mucosal vaccine candidate to boost pulmonary immunity against SARS-CoV-2.
- Subjects
COVID-19 vaccines; MATERNALLY acquired immunity; VACCINATION; VIRUS diseases; SARS-CoV-2; IMMUNITY; CHICKEN diseases
- Publication
NPJ Vaccines, 2023, Vol 8, Issue 1, p1
- ISSN
2059-0105
- Publication type
Article
- DOI
10.1038/s41541-023-00753-4