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- Title
L'asma grave equino: un modello spontaneo di asma neutrofilico.
- Authors
Bullone, Michela
- Abstract
The pathological mechanisms leading to neutrophilic asthma are only partly understood. A dysregulated innate response and oxidative metabolism have been associated to the neutrophilic asthma phenotype. Other immune mechanisms linking the allergic response, commonly observed in asthma, to neutrophilic inflammation have been described. In this context, studying the severe equine asthma model could reveal biological processes that might be translated or applied to the human asthma field. Severe equine asthma is a naturally-occurring, late-onset, neutrophilic model. Different inflammatory phenotypes have been associated with the disease: predominantly Th2, Th1, and/or Th17. Disease exacerbations are triggered by exposure to environmental antigens such as those commonly found in hay and straw, and disease remission is achieved by means of corticosteroid treatment or prolonged antigen avoidance. This aspect, together with the horse's lifespan, dimensions and easy handling represent advantages of this animal model that allows prospective trials to be performed with no need to sacrifice the animal. In this review article, an overview of the current knowledge on severe equine asthma and its similarities with human neutrophilic asthma is presented, together with some possible research applications.
- Publication
Rassegna di Patologia dell'Apparato Respiratorio, 2018, Vol 33, Issue 1, p8
- ISSN
0033-9563
- Publication type
Article