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- Title
The Levels of Vitamins, Antioxidants and Heavy Metals of Gastric Cancer Patients Before and After Treatment.
- Authors
DOĞAN SÖĞÜTLÜ, İnci; MERT, Nihat; MERT, Handan
- Abstract
Gastric cancer, one of the most important diseases threatening human life, has a different etiology and affects the antioxidant system, mineral and vitamin levels. For this purpose, the study was performed in people who were diagnosed with gastric cancer and came to the Oncology Clinic of the Medical Faculty Research Hospital. A total of 77 subjects were selected as study materials, 30 of whom were healthy, 32 male and 47 female with adenocarcinoma. Prior to the treatment of cancer patients, detailed biochemical analyzes were performed on blood samples taken after chemotherapy. According to the elemental analysis technique the levels of ceruloplasmin, GSH-Px, SOD, retinol acetate and α-tocopherol by Mg, Fe, Zn, Cu, Cd, Pb, Ca and Co of serum and whole blood were measured. GSH-Px, SOD, retinol acetate, α-tocopherol levels were measured for each individual. Mg (p≤0.001), Fe (p≤0.05), Ca (p≤0.01) were significantly different, but there was no statistically significant difference between the groups. Although there were differences between the groups in the other parameters examined, no statistical significance was found. Ceruloplasmin, GSH-Px levels were significantly reduced in cancer patients before treatment compared to controls (p≤0,0001), whereas levels of SOD, retinol acetate (p≤0.07) and α-tocopherol (p≤0.05) were increased before treatment of cancer patients. As a result, changes in the levels of elements, enzymes, vitamins and antioxidants have been observed in gastric cancer, especially after administration of Cisplatin, decrease in serum Mg and ceruloplasmin and increase in SOD activity is remarkable.
- Subjects
STOMACH cancer; HEAVY metals; CANCER patients; MEDICAL research; VITAMINS; CERULOPLASMIN; ANTIOXIDANTS
- Publication
Van Veterinary Journal, 2019, Vol 30, Issue 2, p127
- ISSN
2149-3359
- Publication type
Article