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- Title
Local Flexibility of a New Single-Ring Chaperonin Encoded by Bacteriophage AR9 Bacillus subtilis.
- Authors
Sokolova, Olga S.; Pichkur, Evgeny B.; Maslova, Ekaterina S.; Kurochkina, Lidia P.; Semenyuk, Pavel I.; Konarev, Petr V.; Samygina, Valeriya R.; Stanishneva-Konovalova, Tatiana B.
- Abstract
Chaperonins, a family of molecular chaperones, assist protein folding in all domains of life. They are classified into two groups: bacterial variants and those present in endosymbiotic organelles of eukaryotes belong to group I, while group II includes chaperonins from the cytosol of archaea and eukaryotes. Recently, chaperonins of a prospective new group were discovered in giant bacteriophages; however, structures have been determined for only two of them. Here, using cryo-EM, we resolved a structure of a new chaperonin encoded by gene 228 of phage AR9 B. subtilis. This structure has similarities and differences with members of both groups, as well as with other known phage chaperonins, which further proves their diversity.
- Subjects
BACILLUS subtilis; MOLECULAR chaperones; BACTERIOPHAGES; PROTEIN folding
- Publication
Biomedicines, 2022, Vol 10, Issue 10, pN.PAG
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10102347