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- Title
Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas.
- Authors
Danilov, D. V.; D'yachenko, V. S.; Kuznetsov, Y. P.; Burmistrov, V. V.; Butov, G. M.
- Abstract
A series of 1,3-disubstituted ureas containing a lipophilic adamantane moiety tethered to the ureido group by a methylene bridge were synthesized by the reaction of 1-(isocyanatomethyl)adamantane with monohalo- and dihaloanilines in yields of up to 92%. The synthesized ureas are target oriented inhibitors of human soluble epoxide hydrolase (sEH).
- Subjects
EPOXIDE hydrolase; UREA; ADAMANTANE derivatives; METHYLENE group; ADAMANTANE; PHENYL ethers
- Publication
Russian Journal of Organic Chemistry, 2021, Vol 57, Issue 2, p143
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428021020020