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- Title
Synthesis of Bicyclic Isocyanates and Bioisosteric 1,3-Disubstituted Ureas as Soluble Epoxide Hydrolase Inhibitors.
- Authors
Burmistrov, V. V.; D'yachenko, V. S.; Rasskazova, E. V.; Butov, G. M.
- Abstract
(1S)-1-Isocyanato-4,7,7-trimethyl-2-oxabicyclo[2.2.1]heptan-3-one and 2-isocyanatobicyclo[2.2.1]-hept-5-ene were prepared by the Curtius rearragement reaction from the corresponding carboxylic acids. The synthesized isocyanates were used to synthesize, in high yields of 74–93%, bioisosteric 1,3-disubstituted ureas as potential human soluble epoxide hydrolase inhibitors.
- Subjects
EPOXIDE hydrolase; UREA; ISOCYANATES; CARBOXYLIC acids; HYDROLASES
- Publication
Russian Journal of Organic Chemistry, 2019, Vol 55, Issue 8, p1166
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428019080165