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- Title
The action of the gene prune (pn) in Drosophila melanogaster.
- Authors
Lifschytz, Eliezer; Falk, Raphael
- Abstract
The gene pn was found to be active already in larvae 30 h old, long before eye-pteridines accumulated. At this developmental stage pn interacts with the gene K-pn. From studies with induced somatic recombination, gynandromorphs, and induced pn mutations, in a K-pn background it was concluded that the interaction pn-K-pn is non-autonomous in the epidermis, but in some internal organs it is apparently autonomous and causes the death of pn–K-pn flies. It is proposed that pn mutants interfere with an early step of the conversion of guanosine to pteridine, so that a deficiency of drosopterines, but not of the competing sepiapterine and biopterine, is caused. The accumulated precursor is presumably the substrate for a poisonous reaction triggered by K-pn.
- Publication
Genetics Research, 1969, Vol 14, Issue 1, p53
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300001841