We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Outpatient administration of CAR T-cell therapy: a focused review with recommendations for implementation in community based centers.
- Authors
Perez, Ariel; Al Sagheer, Tiba; Nahas, George R.; Linhares, Yuliya P. L.
- Abstract
Chimeric Antigen Receptor T-cell (CAR-T) therapy has transformed the treatment landscape for hematological malignancies, showing high efficacy in patients with relapsed or refractory (R/R) disease and otherwise poor prognosis in the pre-CART era. These therapies have been usually administered in the inpatient setting due to the risk of cytokine release syndrome (CRS) and immune effector cellassociated neurotoxicity syndrome (ICANS). However, there is a growing interest in the transition to outpatient administration due to multiple reasons. We review available evidence regarding safety and feasibility of outpatient administration of CD19 targeted and BCMA targeted CAR T-cell therapy with an emphasis on the implementation of outpatient CAR-T programs in community-based centers.
- Subjects
COMMUNITY centers; CYTOKINE release syndrome; T cells; CHIMERIC antigen receptors; COMMUNITY-based programs; IMMUNE reconstitution inflammatory syndrome
- Publication
Frontiers in Immunology, 2024, p01
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1412002