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- Title
Recurrent short-lasting headache associated with paroxysmal hypertension: a clonidine-responsive syndrome.
- Authors
Dodick, DW; Dodick, D W
- Abstract
The clinical syndrome of hypertension, headache, palpitation, diaphoresis, flushing, and emotional lability is classically associated with pheochromocytoma. Two patients are presented with this constellation of symptoms in whom investigations for pheochromocytoma were unrevealing. Headache was the presenting and most prominent complaint, with daily episodes of short-lasting, intermittent, and paroxysmal attacks. Each paroxysm of headache was associated with a dramatic increase in systolic and diastolic blood pressure. After failure to control the labile fluctuations in blood pressure and headache with several classes of anti-hypertensive medications used in combination, a prompt and persistent response occurred after the administration of clonidine. The pathophysiology of this syndrome and the mechanism of clonidine action are reviewed in the context of a possible failure of the baroreceptor reflex.
- Subjects
PHEOCHROMOCYTOMA; HEADACHE diagnosis; DIAGNOSIS
- Publication
Cephalalgia, 2000, Vol 20, Issue 5, p509
- ISSN
0333-1024
- Publication type
journal article
- DOI
10.1046/j.1468-2982.2000.00073.x