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- Title
Diminished neutralizing activity against the XBB1.5 strain in 55.9% of individuals post 6 months COVID-19 mRNA booster vaccination: insights from a pseudovirus assay on 1,353 participants in the Fukushima vaccination community survey, Japan.
- Authors
Tianchen Zhao; Yuta Tani; Chieko Makino-Okamura; Morihito Takita; Chika Yamamoto; Eiki Kawahara; Toshiki Abe; Sota Sugiura; Hiroki Yoshimura; Taiga Uchiyama; Isato Yamazaki; Harumichi Ishigame; Takaharu Ueno; Kazu Okuma; Masatoshi Wakui; Hidehiro Fukuyama; Masaharu Tsubokura
- Abstract
This study investigates the neutralizing activity against the XBB1.5 variant and the ancestral strain in a population post-bivalent vaccination using a pseudo virus assay validated with authentic virus assay. While bivalent booster vaccination and past infections enhanced neutralization against the XBB 1.5 strain, individuals with comorbidities showed reduced responses. The study suggests the need for continuous vaccine updates to address emerging SARS-CoV-2 variants and highlights the importance of monitoring real-world immune responses.
- Subjects
FUKUSHIMA-shi (Japan); JAPAN; BOOSTER vaccines; VACCINATION; SARS-CoV-2; COVID-19; MESSENGER RNA
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1337520