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- Title
NEW METHODS FOR SURFACE ULTRASTRUCTURE: COMPARATIVE STUDIES OF SCANNING ELECTRON MICROSCOPY, TRANSMISSION ELECTRON MICROSCOPY AND REPLICA METHOD.
- Authors
Hashimoto, Ken
- Abstract
The article discusses new methods for surface ultrastructure. Scanning electron microscope became a practical tool in biological application in 1964-1966. The primary electron beam generated in this instrument is not meant to pass through the specimen to form an image, but to produce secondary electrons when it impinges upon the specimen surface and scans the surface. The secondary electrons coming from various parts of the scanned surface differ in amount. The freeze-fracture method is a powerful tool for examining a large area of cell membrane; conveniently, the space between the inner and outer leaflets is the most common site of cleavage in the epidermis, and the cell membrane is an important subject in the study of cancer these days.
- Subjects
ULTRASTRUCTURE (Biology); SCANNING electron microscopes; ELECTRONS; FREEZE fracturing; CELL membranes; EPIDERMIS
- Publication
International Journal of Dermatology, 1974, Vol 13, Issue 6, p357
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/j.1365-4362.1974.tb05068.x