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- Title
Diagnostyka i postępowanie terapeutyczne w opryszczkowatym zapaleniu skóry (chorobie Duhringa) - konsensus Polskiego Towarzystwa Dermatologicznego.
- Authors
Żebrowska, Agnieszka; Waszczykowska, Elżbieta; Kowalewski, Cezary; Woźniak, Katarzyna; Olszewska, Małgorzata; Placek, Waldemar; Czajkowski, Rafał; Szepietowski, Jacek; Białynicki-Birula, Rafał; Dmochowski, Marian
- Abstract
Dermatitis herpetiformis (Duhring's disease) is an autoimmune blistering dermatosis with a characteristic polymorphic, itchy rash. The autoimmune process against transglutaminases (TGs) is connected with asymptomatic or with mild symptoms of gluten-sensitive enteropathy (GSE). The diagnostic approach in DH should rely on clinical evaluation, direct immunofluorescence of perilesional skin and evaluation of serum IgA antibodies with ELISA with one substrate of four substrates from which to choose (tTG, eTG, npG, neo-tTG) using the ELISA method. In cases showing an equivocal clinical-laboratory picture such an approach should be broadened by performing histopathology of lesional skin and examining the HLA DQ2/DQ8 haplotype. Combined treatment with dapsone and a gluten-free diet in individualized combinations is generally the therapeutic method of choice in DH
- Subjects
DERMATITIS herpetiformis; IMMUNOFLUORESCENCE; HISTOPATHOLOGY; DIAGNOSIS; THERAPEUTICS
- Publication
Dermatology Review / Przeglad Dermatologiczny, 2016, Vol 103, Issue 2, p95
- ISSN
0033-2526
- Publication type
Article
- DOI
10.5114/dr.2016.59130