We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cryofibrinogenemia and skin necrosis in a patient with diffuse large cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation.
- Authors
Shimoni, A; Körbling, M; Champlin, R; Molldrem, J
- Abstract
A 34-year-old woman with diffuse mediastinal B cell large cell lymphoma presented 60 days after high-dose chemotherapy and autologous stem cell transplantation, and post-transplant immunotherapy with interleukin-2, with skin necrosis in the ears and extremities. Extensive work-up revealed the presence of cryofibrinogenemia and associated thrombotic vasculopathy. The patient was successfully treated with corticosteroids and therapeutic plasma exchange. However, she had recurrence of large cell lymphoma a few weeks later and died of progressive disease. Cryfibrinogenemia and skin necrosis may have occurred secondary to the imminent relapse, or as a rare complication of high-dose chemotherapy or treatment with interleukin-2. Bone Marrow Transplantation (2000) 26, 1343–1345.
- Subjects
B cells; LYMPHOMAS; DRUG therapy; AUTOTRANSPLANTATION; STEM cell transplantation
- Publication
Bone Marrow Transplantation, 2000, Vol 26, Issue 12, p1343
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1702678