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- Title
Potential application of thermo-sensitive hydrogels for controlled release of phenacetin.
- Authors
Ilić-Stojanović, Snežana S.; Nikolić, LjubiŠa B.; Nikolić, Vesna D.; Milić, Jela R.; Petrović, Slobodan D.; Nikolić, Goran M.; Kapor, AgneŠ J.
- Abstract
Over the past years, many scientific research studies have been focused on thermo-sensitive hydrogels containing N-isopropylacrylamide (NIPAM) as a monomer. The NIPAM based hydrogels with 20 mol% 2-hydroxypropyl methacrylate (HPMet) were synthesized using ethylene glycol dimethacrylate as a cross-linker. The characterization of xerogel and phenacetin using Fourier transform infrared (FTIR) spectroscopy and Scanning electron microscopy (SEM)confirm the performed synthesis with satisfactory purity as well as loading of phenacetin into hydrogel. The swelling transport mechanism at simulated physiological conditions (pH 2.20 and 7.40 at 37 °C) is described by the time-independent kinetics. The potential application of synthesized hydrogels for the controlled release of phenacetin as a model drug was investigated at simulated physiological conditions by HPLC method
- Subjects
HYDROGELS; PHENACETIN; METHACRYLATES; MONOMERS; ETHYLENE glycol; FOURIER transform infrared spectroscopy; SCANNING electron microscopy; HIGH performance liquid chromatography
- Publication
Chemical Industry / Hemijska Industrija, 2012, Vol 66, Issue 6, p831
- ISSN
0367-598X
- Publication type
Article
- DOI
10.2298/HEMIND120222089I