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- Title
OSTEODYSTROPHY IN CHRONIC VIRAL HEPATITIS C - AN UNDERDIAGNOSED PATHOLOGY.
- Authors
Barbu, Ecaterina-Constanţa; Chiţu-Tişu, Cristina-Emilia; Lazăr, Mihai; Ion, Daniela Adriana; Bădărău, Ioana Anca
- Abstract
Objectives. Hepatic osteodystrophy represents the impairment of bone structure in patients with chronic liver disease. It is characterized by reduced bone mineral density, defined as osteoporosis/osteopenia. It is an important complication of viral liver disease, frequently underdiagnosed and, therefore, untreated. The objectives of this study were to determine the prevalence of osteodystrophy in patients with chronic viral hepatitis C and to identify the factors correlated with its severity. Material and methods. We performed a cohort study on 40 patients with chronic viral hepatitis C in order to assess global and segmental bone mineral density using osteodensitometry (DEXA, Dual Energy X-ray Absorptiometry) and to correlate bone mineral density changes with anthropometric parameters, biochemical, virological markers, non-invasive liver fibrosis assessment and treatment. Results. The overall prevalence of demineralization was high, 52.5% (n=21). In patients aged <50 years, the prevalence of low bone mineral density (BMD) was 23.07% (n=3), and in patients aged ≥50 years old or more, the demineralization prevalence was 18% (n=5) for osteoporosis and 48.14% (n= 3) for osteopenia. Furthermore, the data support a greater decrease in BMD in certain lumbar vertebrae (L1 and L3) and hip specific areas (area of the Ward triangle). Decreased bone mineral density significantly correlated with age, smoking, low body mass index (BMI), presence of liver cytolysis. Conclusions. It is necessary to assess early bone changes in chronic hepatitis C patients and start timely the antiosteoporotic treatment, in order to decrease fracture risk.
- Publication
Internal Medicine / Medicină Internă, 2015, Vol 12, Issue 5, p55
- ISSN
1220-5818
- Publication type
Article