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- Title
Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia.
- Authors
Romero-Benavides, Juan Carlos; Ortega-Torres, Gina C.; Villacis, Javier; Vivanco-Jaramillo, Sara L.; Galarza-Urgilés, Karla I.; Bailon-Moscoso, Natalia
- Abstract
Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma (D-384), and breast (MCF-7). The methanolic extract displayed the largest substantial cytotoxic effect in lines of colon cancer (RKO) and cerebral astrocytoma (D-384). Chromatographic purification of the B. obtusifolia methanolic extract led to the isolation and identification of 5,4′-dihydroxy-7-methoxyflavone (1) and 5-hydroxy-7,4′-dimethoxyflavone (2) compounds of the flavonoid type.
- Subjects
PHARMACEUTICAL chemistry; PHYTOCHEMICALS; BACCHARIS; FLAVONOIDS; PROSTATE cancer prevention; THERAPEUTICS
- Publication
International Journal of Medicinal Chemistry, 2018, p1
- ISSN
2090-2069
- Publication type
Article
- DOI
10.1155/2018/8908435