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- Title
Three-component anti selective Mannich reactions in a tetrahydro-4-pyranone system by using PDAG-Co catalyst.
- Authors
Abaee, M. Saeed; Akbarzadeh, Elahe; Shockravi, Abbas; Mojtahedi, Mohammad M.; Mehraki, Ehsan; Khavasi, Hamid Reza
- Abstract
Catalytic quantities (2 mol%) of a complex of cobalt containing guanidine and 2,6-pyridinedicarboxylic acid ligands (PDAG-Co) were used for the efficient three-component Mannich reactions of tetrahydro-4-pyranone ( 1) with different aromatic aldehydes and aniline derivatives in a one-pot process. Reactions rapidly gave high yields of the corresponding three-substituted tetrahydro-4-pyranones at room temperature. Spectroscopic and X-ray analyses support the formation of anti diastereomers as the major or sole products of the reactions.
- Subjects
HETEROCYCLIC compounds synthesis; GUANIDINE derivatives; CARBOXYLIC acids; CHEMICAL synthesis; MANNICH reaction; PYRANONES synthesis; AROMATIC aldehydes; AROMATIC compound synthesis
- Publication
Heterocyclic Communications, 2014, Vol 20, Issue 2, p123
- ISSN
0793-0283
- Publication type
Article
- DOI
10.1515/hc-2014-0001