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- Title
Periodical Appearance of Erythropoietin-Independent Erythropoiesis in Chronic Myelogenous Leukemia with Cyclic Oscillation1.
- Authors
Umemura, Tsukuru; Hirata, Jouji; Kaneko, Shushi; Nishimura, Junji; Motomura, Seiji; Kozuru, Mitsuo; Ibayashi, Hiroshi
- Abstract
A patient with Ph1 -positive chronic myelogenous leukemia (chronic phase) had a cyclic oscillation in white blood cells, platelets and percent saturation of transferrin. The cycle comprised about 70 days. The number of circulating granulocyte-macrophage colony-forming units (CFU-GM) oscillated with the same phase, while that of bone marrow CFU-GM and erythroid colony-forming units (CFU-E) oscillated in a reverse phase. At the nadir, we observed an abnormal increase in bone marrow endogenous CFU-E (e-CFU-E). An erythropoietin (Epo) dose-response curve of CFU-E showed a high Epo-sensitivity. Anti-Epo rabbit serum did not inhibit the e-CFU-E colony formation. This indicates that Epo-independent erythropoiesis occurs periodically at the nadir. It is suggested that the interactions between the abnormal stem cell and the hematopoietic regulating system cause cyclic oscillation. Copyright © 1986 S. Karger AG, Basel
- Publication
Acta Haematologica, 1986, Vol 76, Issue 4, p230
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000206062