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- Title
Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas.
- Authors
Pinkney, Kerice A.; Wenxia Jiang; Lee, Brian J.; Loredan, Denis G.; Chen Li; Bhagat, Govind; Shan Zha
- Abstract
Bcl11b is a transcription factor important for T cell development and also a tumor-suppressor gene that is hemizygously inactivated in ∼10 % human T cell acute lymphoblastic leukemia (T-ALL) and several murine T-ALL models, including ATM-/- thymic lymphomas. Here we report that heterozygous loss of Bcl11b (Bcl11b+/-) unexpectedly reduced lethal thymic lymphoma in ATM-/- mice by suppressing lymphoma progression, but not initiation. The suppression was associated with a T cell-mediated immune response in ATM-/-Bcl11b+/- mice, revealing a haploid insufficient function of Bcl11b in immune modulation against lymphoma and offering an explanation for the complex relationship between Bcl11b status with T-ALL prognosis.
- Subjects
TRANSCRIPTION factors; RETICULOENDOTHELIAL granulomas; LYMPHOMAS; TUMOR suppressor genes; LOSS of heterozygosity
- Publication
Journal of Hematology & Oncology, 2015, Vol 8, Issue 1, p1
- ISSN
1756-8722
- Publication type
Article
- DOI
10.1186/s13045-015-0191-8