We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cost analysis of pharmaceutical care provided to HIV-infected patients: an ambispective controlled study.
- Authors
Cavalcanti Carnevale, Renata; Rezende Costa Molino, Caroline de Godoi; Berlofa Visacri, Marília; Gava Mazzola, Priscila; Moriel, Patricia
- Abstract
Background: Studies have shown that pharmaceutical care can result in favorable clinical outcomes in human immunodeficiency virus (HIV)-infected patients, however, few studies have assessed the economic impact. The objective of this study was to evaluate the clinical and economic impact of pharmaceutical care of HIV-infected patients. Methods: A controlled ambispective study was conducted in Brazil from January 2009 to June 2012. Patients were allocated to either intervention or control group. The control group was followed according to standard care while the intervention group was also followed by a pharmacist at each physician appointment for one year. Effectiveness outcomes included CD4+ count, viral load, absence of co-infections and optimal immune response, and economic outcomes included expenses of physician and pharmaceutical appointments, laboratory tests, procedures, and hospitalizations, at six months and one year. Results: Intervention and control groups included 51 patients each. We observed significant decreases in total pharmacotherapy problems during the study. At six months, the intervention group contained higher percentages of patients without co-infections and of patients with CD4+ >500 cells/mm³. None of the differences between intervention and control group considering clinical outcomes and costs were statistically significant. However, at one year, the intervention group showed higher percentage of better clinical outcomes and generated lower spending (not to procedures). An additional health care system daily investment of US$1.45, 1.09, 2.13, 4.35, 1.09, and 0.87 would be required for each additional outcome of viral load <50 copies/ml, absence of co-infection, CD4+ >200, 350, and 500 cells/mm3, and optimal immune response, respectively. Conclusion: This work demonstrated that pharmaceutical care of HIV-infected patients, for a one-year period, was able to decrease the number of pharmacotherapy problems. However, the clinical outcomes and the costs did not have statistical difference but showed higher percentage of better clinical outcomes and lower costs for some items.
- Subjects
DIAGNOSIS of HIV infections; HIV infections; THERAPEUTICS; COST analysis; BLACK people; ECONOMICS; HEPATITIS C; HIV-positive persons; MEDICAL care; EVALUATION of medical care; PATIENTS; PHARMACISTS; PHARMACOLOGY; RESEARCH funding; SMOKING; TOXOPLASMOSIS; TUBERCULOSIS; WHITE people; VIRAL load; ANTIRETROVIRAL agents; CONTROL groups; CASE-control method; DATA analysis software; CD4 lymphocyte count; IMMUNOCOMPROMISED patients; MIXED infections; DISEASE complications
- Publication
DARU: Journal of Pharmaceutical Sciences, 2015, Vol 23, p1
- ISSN
1560-8115
- Publication type
journal article
- DOI
10.1186/s40199-014-0074-5