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- Title
Structural characterization of N-lignoceroyl (C24:0) sphingomyelin bilayer membranes: a re-evaluation.
- Authors
Takahashi, Hiroshi; Hayakawa, Tomohiro; Kawasaki, Yuko; Ito, Kazuki; Fujisawa, Tetsuro; Kodama, Michiko; Kobayashi, Toshihide
- Abstract
Sphingomyelin (SM) is a membrane lipid and plays important roles in signaling, protein trafficking, cell growth and death. The structure of the bilayer of a hydrated highly asymmetric SM, N-lignoceroyl (C24:0) SM, has been investigated with X-ray diffraction (XRD), simultaneous small-angle X-ray scattering (SAXS), wide-angle XRD and SAXS. At temperatures between two endothermic transitions of hydrated C24:0 SM bilayers, the C24:0 SM formed a ripple phase with the ripple periodicity of ~12–14 nm. At about three months incubation at 277 K, the formation of a stable phase with a short lamellar spacing of 5.62 nm was induced. Based upon the structures revealed by this study and the phase behavior, intermolecular interactions between C24:0 SM molecules in the bilayer membrane are discussed.
- Subjects
X-ray scattering; SMALL-angle X-ray scattering; MEMBRANE lipids; GROWTH factors; APOPTOSIS; CELL death
- Publication
Journal of Applied Crystallography, 2007, Vol 40, ps312
- ISSN
0021-8898
- Publication type
Article
- DOI
10.1107/S002188980700859X