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- Title
Neurodevelopmental trajectories in children with cleft lip and palate: A longitudinal study based on the Japan Environment and Children's Study.
- Authors
Tsuchiya, Shinobu; Tsuchiya, Masahiro; Momma, Haruki; Aida, Jun; Nagatomi, Ryoichi; Yaegashi, Nobuo; Arima, Takahiro; Igarashi, Kaoru
- Abstract
Cleft lip and/or palate (CL/P), the most prevalent congenital anomaly, is understood to negatively affect a wide range of child development. Since the concept remains controversial, because most published work is from cross‐sectional studies, we examined the neurodevelopmental trajectories in participants with CL/P through a longitudinal comparison with the general population during early childhood using data from a nationwide birth cohort study in Japan. The linear mixed models for each domain of the Ages and Stages Questionnaire, third edition (ASQ‐3), were used to detect differences in standardised mean scores between groups. The ASQ‐3 is a general neurodevelopmental screening tool comprising communication, gross motor, fine motor, problem‐solving, and personal‐social domains. Participants' neurodevelopment was determined semi‐annually from 6 to 36 months of age. The trajectories of standardised mean scores in each domain showed several significant differences between the control and CL/P groups, with the maximum difference at 24 months of age in the communication domain. Indeed, CL/P was associated with significantly lower scores in the communication (coefficient: –3.31, 95% CI: –5.09 to –1.14), problem‐solving (coefficient: –3.13, 95% CI: –5.07 to –1.18), and personal‐social domains (coefficient: –1.99, 95% CI: –3.87 to –0.11). Trajectories of ASQ‐3 scores suggest neurodevelopmental delays in children with CL/P.
- Subjects
JAPAN; PROBLEM solving; CONFIDENCE intervals; CHILD development; CROSS-sectional method; CLEFT palate; CLEFT lip; RISK assessment; CHILD psychopathology; QUESTIONNAIRES; COMMUNICATION; LONGITUDINAL method; MOTOR ability; DISEASE complications
- Publication
European Journal of Oral Sciences, 2022, Vol 130, Issue 2, p1
- ISSN
0909-8836
- Publication type
Article
- DOI
10.1111/eos.12857