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- Title
Abnormal Anterior Pituitary Responsiveness to Hypothalamic Hormones in Primary Affective Disorders.
- Authors
Brambilla, F.; Scarone, S.; Massironi, R.; Nobile, P.; Pugnetti, L.
- Abstract
Abnormal anterior pituitary responsiveness to acute administration of thyrotropin-releasing hormone was investigated in 8 patients, 6 women and 2 men, with primary affective disorders in a depressive phase and in 2 women with schizoaffective disorders. Thyrotropin-releasing hormone, 500 μg i.v., induced a rise of plasma growth hormone levels in 1 patient suffering from primary affective disorders and in the 2 schizoaffective subjects, a rise of follicle-stimulating hormone in 1 schizoaffective patient, of luteinizing hormone in the 2 schizoaffective patients, an excessive prolactin rise in 5 patients with primary affective disorders and in 1 schizoaffective subject and a flat response of thyroid-stimulating hormone in 4 patients with primary affective disorders and in 2 schizoaffective patients. Desimipramine was given at a dose of 50-100 mg/day for 3-5 weeks. The thyrotropin-releasing hormone stimulation test was repeated when the patients were improving or after 5 weeks of treatment without improvement. The hormonal impairments tended to disappear in those patients showing symptomatic improvement and were still present in those who did not improve. Copyright © 1982 S. Karger AG, Basel
- Publication
Neuropsychobiology, 1982, Vol 8, Issue 5, p269
- ISSN
0302-282X
- Publication type
Article
- DOI
10.1159/000117908