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- Title
Usefulness of metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in clinical characterisation of children with newly diagnosed Crohn's disease.
- Authors
Daniluk, Urszula; Daniluk, Jaroslaw; Guzinska‐Ustymowicz, Katarzyna; Pryczynicz, Anna; Lebensztejn, Dariusz; Guzinska-Ustymowicz, Katarzyna
- Abstract
<bold>Aim: </bold>The aim of this study was to determine the relation of non-invasive markers representing gut mucosal damage (metalloproteinase-9 (MMP-9)) and remodelling (tissue inhibitor of metalloproteinase-1 (TIMP-1)) with Crohn's disease (CD) phenotype, disease activity scores (clinical and endoscopic) and radiological evaluation of the ileum in newly diagnosed children.<bold>Methods: </bold>Serum and faecal MMP-9 and TIMP-1 concentrations were determined with the sandwich enzyme-linked immunoassay technique. The performance of each marker with reference to the Paris classification, disease activity scores and magnetic resonance enterography results was assessed using non-parametric tests.<bold>Results: </bold>A total of 32 children with CD demonstrated higher levels of serum and faecal MMP-9 and TIMP-1 compared with a control group including children without gastrointestinal inflammatory disease (all P < 0.05). Only the serum MMP-9 concentration was significantly higher in children with L3 (ileocolonic) compared with children with L1 (distal ileum). The serum TIMP-1 level was significantly higher in patients with an magnetic resonance enterography-detected ileum involvement longer than 51 mm and in children with severe disease activity compared with other patients. The serum MMP-9 level was lower in patients with stenosis combined with prestenotic dilation compared with children without stenosis.<bold>Conclusion: </bold>Increased serum and faecal MMP-9 and TIMP-1 concentrations are some reliable markers of inflammation in newly diagnosed children with CD, but without facilitating clear phenotyping of the disease.
- Subjects
PARIS (France); CROHN'S disease; CALPROTECTIN; MAGNETIC resonance; JUVENILE diseases; GASTROINTESTINAL diseases; PROTEINS; PROTEOLYTIC enzymes; MAGNETIC resonance imaging; TISSUE inhibitors of metalloproteinases; RESEARCH funding
- Publication
Journal of Paediatrics & Child Health, 2020, Vol 56, Issue 8, p1233
- ISSN
1034-4810
- Publication type
journal article
- DOI
10.1111/jpc.14908