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- Title
Diversity and regulation of amiloride-sensitive Na+ channels.
- Authors
Benos, Dale J.; Awayda, Mouhamed S.; Berdiev, Bakhram K.; Bradford, Anne Lynn; Fuller, Catherine M.; Senyk, Oksana; Ismailov, Iskander I.; Benos, D J; Awayda, M S; Berdiev, B K; Bradford, A L; Fuller, C M; Senyk, O; Ismailov, I I
- Abstract
Amiloride-sensitive Na+ channels play a vital role in many important physiological processes such as delineation of the final urine composition, sensory transduction, and whole-body Na+ homeostasis. These channels display a wide range of biophysical properties, and are regulated by cAMP-mediated second messenger systems. The first of these channels has recently been cloned. This cloned amiloride-sensitive Na+ channel is termined ENaC (Epithelial Na+ Channel) and, in heterologous cellular expression systems, displays a single channel conductance of 4 to 7 pS, a high PNa/PK (> 10), a high amiloride sensitivity (Ki(amil) = 150 nM), and relatively long open and closed times. ENaC may form the core conduction element of many of these functionally diverse forms of Na+ channel. The kinetic and regulatory differences between these channels may be due, in large measure, to unique polypeptides that associate with the core element, forming a functional channel unit.
- Subjects
SODIUM channels; AMILORIDE; URINE; GENETIC transduction; PEPTIDES; ION channels
- Publication
Kidney International, 1996, Vol 49, Issue 6, p1632
- ISSN
0085-2538
- Publication type
journal article
- DOI
10.1038/ki.1996.237