We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reduced capillary density in the myocardium of uremic rats--a stereological study.
- Authors
Amann, Kerstin; Wiest, Gabriele; Zimmer, Gisela; Gretz, Norbert; Ritz, Eberhard; Mall, Gerhard; Amann, K; Wiest, G; Zimmer, G; Gretz, N; Ritz, E; Mall, G
- Abstract
Using stereological techniques capillaries, interstitium and myocardial fibers were analyzed in perfusion-fixed hearts of subtotally nephrectomized male Sprague-Dawley rats with uremia of 14 months duration (or their sham-operated controls). Uremic rats had higher systolic blood pressure (140 +/- 20.3 mm Hg vs. 119 +/- 6.61 mm Hg) and left ventricular weight/body weight ratio (3.37 +/- 0.09 mg/kg vs. 2.01 +/- 0.12 mg/kg) than controls, and had slight anemia (Hct 35.0 +/- 3.16% vs. 40.4 +/- 3.3%). Length density (Lv) of capillaries, that is, capillary length per unit myocardial volume, was significantly (P < 0.001) decreased in uremia (2485 +/- 264 mm/mm3 vs. 3329 +/- 194 mm/mm3) versus controls. In parallel, surface density and volume density of the capillary lumina were also reduced (7.95 +/- 1.69 cm3/cm3 vs. 11.4 +/- 1.8 cm3/cm3) in the uremic rats. We conclude that in experimental uremia, cardiac hypertrophy is not accompanied by a commensurate increase in capillaries.
- Subjects
NEPHROLOGY; UREMIA; KIDNEY diseases; MYOCARDIAL infarction; CARDIAC hypertrophy; CAPILLARIES; BLOOD vessels; LABORATORY rats; BIOLOGICAL models; MYOCARDIUM; ANIMAL experimentation; RATS; ELECTRON microscopy; CORONARY arteries; CYTOPLASM; DISEASE complications
- Publication
Kidney International, 1992, Vol 42, Issue 5, p1079
- ISSN
0085-2538
- Publication type
journal article
- DOI
10.1038/ki.1992.390