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- Title
Beta[sub2]-microglobulin deposition in bone in chronic renal failure.
- Authors
Onishi, Shuhei; Andress, Dennis L.; Maloney, Norma A.; Coburn, Jack W.; Sherrard, Donald J.
- Abstract
Recently, there have been reports of beta2-microglobulin (β2m) related amyloid deposition in perineural and periarticular tissues in patients receiving long-term hemodialysis, but it has been rarely described in bone. We, therefore, examined previously obtained bone biopsy specimens in patients receiving long-term hemodialysis to determine the prevalence of β2m deposition in bone and to assess the relationship between β2m deposits and bone histomorphometry. We found β2m deposits in bone in 8% of 224 patients examined. Bone deposition of β2m was absent in patients who were on dialysis for less than six years, but was present it in 19% who dialyzed longer than 10 years. β2m deposits were found in specimens from the iliac crest, femoral bone, tibia, vertebra and rib. In the iliac crest β2m deposition was localized predominantly to the periosteum. Among these patients with β2m in iliac crest periosteum, 62% had suffered a femoral neck fracture compared to only 4% of matched patients who had negative staining for β2m in the iliac crest (P < 0.001). Histologically, osteitis fibrosa seemed more common in patients positive for β2m than in patients negative for β2m deposition. We conclude that β2m deposition in bone is common in uremic patients who have received hemodialysis longer than 10 years. The high prevalence of femoral neck fracture in patients with β2m localized to the periosteum of the iliac crest suggests that this involvement may be useful to predict susceptibility to femoral fracture.
- Subjects
GLOBULINS; BONES; CHRONIC kidney failure; AMYLOID; HEMODIALYSIS; PATIENTS
- Publication
Kidney International, 1991, Vol 39, Issue 5, p990
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1991.125