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- Title
Transarterial Chemo and Radioembolization (Yttrium90) of Hepatic Metastasis of Neuroendocrine Tumors: Single Center Experience.
- Authors
OZKAN, Fuat; PEYNIRCIOGLU, Bora; CIL, Barbaros E.; YURTTUTAN, Nursel; YALCIN, Suayib; BALKANCI, Ferhun
- Abstract
The aim of this study was to present our single center experience with short (< 3 months) and intermediate-term (> 3 months) follow- up results of patients who underwent transarterial radioembolization with yttrium-90 microsphere (Y-90) or transarterial chemoembolization (TACE) for hepatic metastasis of neuroendocrine tumors (hmNETs). The results of 14 patients treated with either Y-90 or TACE were reviewed retrospectively. Clinical, laboratory, and imaging follow-up was performed. Efficacy was assessed by clinical and morphologic response. Survival was estimated by Kaplan-Meier analysis. Eight patients receiving 12 TACE treatments and 6 patients receiving 7 Y-90 treatments. Response rates were similar with two treatments at short-term follow-up, but there were a lower response rate and higher being progressive disease in the TACE group than Y-90 group at intermediate-term follow-up. However, progression-free survival was lower in Y-90 group (7.5 months) than TACE group (18 months). Regarding our limited experience, both Y-90 treatment and TACE have advantages and disadvantages in treatment of patients with hmNETs, however, randomized controlled studies, are needed.
- Subjects
RADIOEMBOLIZATION; LIVER metastasis; NEUROENDOCRINE tumors; MICROSPHERES; KAPLAN-Meier estimator; DRUG efficacy
- Publication
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi, 2013, Vol 23, Issue 1, p20
- ISSN
1306-133X
- Publication type
Article
- DOI
10.4999/uhod.12038