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- Title
Elevated Granulocyte Colony-stimulating Factor Levels in Patients With Active Phase of Adult-onset Still Disease.
- Authors
Yudong Liu; Shulan Zhang; Chang-sheng Xia; Jiali Chen; Chunhong Fan; Liu, Yudong; Zhang, Shulan; Xia, Chang-Sheng; Chen, Jiali; Fan, Chunhong
- Abstract
<bold>Objective: </bold>Neutrophilia is a hallmark of adult-onset Still disease (AOSD). We aimed to investigate the levels of granulocyte colony-stimulating factor (G-CSF), an essential regulator of neutrophil production and function, in the pathogenesis of AOSD.<bold>Methods: </bold>Sera were collected from 70 patients with AOSD and 20 healthy controls (HCs). The levels of G-CSF were determined by ELISA. Low-density granulocytes (LDGs) were quantified by flow cytometry. Correlations between G-CSF levels and disease activity, laboratory variables, and LDG levels in patients with AOSD were analyzed by Spearman correlation test.<bold>Results: </bold>Patients with active AOSD presented significantly higher levels of G-CSF compared to inactive AOSD patients (P < 0.001) and HCs (P < 0.0001). The G-CSF levels were significantly decreased after active AOSD patients achieved disease remission (P = 0.0015). The G-CSF levels were significantly correlated with C-reactive protein, erythrocyte sedimentation rate, ferritin, and systemic score in AOSD (P < 0.0001). Significant correlations between the levels of G-CSF and circulating neutrophils (P < 0.0001), neutrophil-to-lymphocyte ratio (P < 0.0001), percentages of LDGs in the peripheral blood mononuclear cells (P = 0.004), as well as absolute numbers of circulating LDGs (P = 0.018) were identified. Patients with fever, evanescent rash, sore throat, arthralgia, myalgia, lymphadenopathy, or hepatomegaly/elevated liver enzymes displayed significantly higher levels of G-CSF compared to patients without these manifestations (P < 0.05).<bold>Conclusion: </bold>Our findings indicate that G-CSF is implicated in the pathogenesis of AOSD, and targeting G-CSF may have therapeutic potential for AOSD. In addition, introducing circulating G-CSF levels into the clinical assessment system may help to monitor disease activity.
- Subjects
RHEUMATOID arthritis; FILGRASTIM; NEUTROPHILS; PATHOLOGY; INFLAMMATION; RESEARCH; GRANULOCYTE-colony stimulating factor; MONONUCLEAR leukocytes; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; LEUKOCYTE count
- Publication
Journal of Rheumatology, 2021, Vol 48, Issue 5, p664
- ISSN
0315-162X
- Publication type
journal article
- DOI
10.3899/jrheum.200617