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- Title
NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
- Authors
Thu, Vu Thi; Kim, Hyoung-Kyu; Long, Le Thanh; Lee, Sung-Ryul; Hanh, Tran My; Ko, Tae Hee; Heo, Hye-Jin; Kim, Nari; Kim, Soon Ha; Ko, Kyung Soo; Rhee, Byoung Doo; Han, Jin
- Abstract
Aims Preservation of mitochondrial function is essential to limit myocardial damage in ischaemic heart disease. We examined the protective effects and mechanism of a new compound, NecroX-5, on rat heart mitochondria in a hypoxia/reoxygenation (HR) model. Methods and results NecroX-5 reduced mitochondrial oxidative stress, prevented the collapse in mitochondrial membrane potential, improved mitochondrial oxygen consumption, and suppressed mitochondrial Ca2+ overload during reoxygenation in an in vitro rat heart HR model. Furthermore, NecroX-5 reduced the ouabain- or histamine-induced increase in mitochondrial Ca2+. Conclusion These findings suggest that NecroX-5 may act as a mitochondrial Ca2+ uniporter inhibitor to protect cardiac mitochondria against HR damage.
- Subjects
HYPOXEMIA; MITOCHONDRIA; CALCIUM; ISCHEMIA; HEART diseases; LABORATORY rats
- Publication
Cardiovascular Research, 2012, Vol 94, Issue 2, p342
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvs122