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- Title
Modulation of the norfloxacin resistance in Staphylococcus aureus by Croton campestris A. and Ocimum gratissimum L.
- Authors
Coutinho, Henrique D. M.; Matias, Edinardo F. F.; Santos, Karla K. A.; Santos, Francisco A. V.; Morais-Braga, Maria Flaviana B.; Souza, Teôgenes M.; Andrade, Jacqueline Cosmo; Souza, Celestina E. S.; Tintino, Saulo R.; Guedes, Glâucia M. M.; Falcâo-Silva, Vivyanne S.; Siqueira-Junior, José P.; Costa, José G. M.
- Abstract
Introduction: Some species of Staphylococcus are often recognized as etiological agents of many animal and human opportunistic infections. This study is the first test of change in resistance of antibiotic activity by Croton campestris A. and Ocimum gratissimum L. against multiresistant strains of Staphylococcus aureus. Objective: In this study, the hexane and methanol extract of Croton campestris A. and Ocimum gratissimum L. was tested for antibacterial activity alone and in combination with norfloxacin against the strain SA1199B. Materials and methods: The minimum inhibitory concentration (MIC) and the modulatory effect of extracts was assayed using microtitre assay. Results: By the fact of the MIC observed was not clinically relevant (MIC= 512 to £1.024 pg/ml), the antibiotic activity of norfloxacin was enhanced when this antibiotic was combined with sub-inhibitory concentrations of extracts, mainly the hexane extracts. Conclusions: These results indicate that the assayed extracts present compounds that can be used as a putative efflux pump inhibitor, indicating that Croton campestris A. and Ocimum gratissimum L. can be a source of plant derived products with antibiotic modifier activity.
- Subjects
NORFLOXACIN; DRUG resistance in microorganisms; STAPHYLOCOCCUS aureus; ETIOLOGY of diseases; OPPORTUNISTIC infections; ANTIBIOTICS; METHANOL; PLANT extracts
- Publication
Biomédica: Revista del Instituto Nacional de Salud, 2011, Vol 31, Issue 4, p608
- ISSN
0120-4157
- Publication type
Article
- DOI
10.7705/biomedica.v31i4.409