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- Title
Peritoneal Protein Losses and Cytokine Generation in Automated Peritoneal Dialysis with Combined Amino Acids and Glucose Solutions.
- Authors
Tjiong, H. L.; Zijlstra, F. J.; Rietveld, T.; Wattimena, J. L.; Huijmans, J. G. M.; Swart, G. R.; Fieren, M. W. J. A.
- Abstract
Objectives. Protein-energy malnutrition as a consequence of deficient protein intake frequently occurs in peritoneal dialysis (PD) patients. Previously, we showed that peritoneal dialysate containing a mixture of amino acids (AA) and g]ucose has anabolic effects. However AA-dialysate has been reported to increase intraperitoneal protein and AA losses and the release of proinflammatorv cytokines (interleukine-6 (IL-6) and tumor necrosis factor alpha (TNFα). We investigated the effect of AA plus glucose (AAG) solutions on peritoneal protein losses and cytokine generation. Methods. In 6 patients on standard automated peritoneal dialysis (APD) 12 APD sessions of 6 cycles each were performed during the night using dialysates containing 1.1% AA plus glucose or glucose alone as control. Protein losses and TNFα and IL-6 concentrations were measured in dialysates separately collected from nightly cycling and daytime dwell. Results. The 24 hour-protein losses with AAG (median 6.7 g, range 4.7-9.4 g) were similar to control dialysate (median 6.0g, range 4.2-9.2g). Daytime dialysate IL-6 levels were higher after nightly AAG dialysis than after control dialysis (142 pg/ml and 82 pg/ml, respectively, P < .05). TNFα concentrations were very low. Conclusion. Nightly APD with amino acids containing dialysate was associated with an increase in peritoneal IL-6 generation during the day. The addition of AA to standard glucose dialysis solutions did not induce a significant increase of peritoneal protein losses.
- Subjects
PROTEINS; CYTOKINES; PERITONEAL dialysis; AMINO acids; GLUCOSE
- Publication
Mediators of Inflammation, 2007, Vol 2007, Issue 2, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2007/97272