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- Title
Getting the T-box dose right.
- Authors
Hatcher, Cathy J.; Basson, Craig T.
- Abstract
Reports on the results of a study of a mouse model of Holt-Oram syndrome, which has been associated with mutations in the T-box transcription factor TBX5. Its function; How mutations in it can cause disease; Results of previous studies; Effects of experimental changes in TBX5 expression on heart and limb development in various species; Influence of genetic background on disease manifestations; Importance of considering species-specific gene expression patterns; Conclusions.
- Subjects
TRANSCRIPTION factors; PROTEINS; MEDICAL genetics; DISEASE risk factors; LABORATORY mice
- Publication
Nature Medicine, 2001, Vol 7, Issue 11, p1185
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm1101-1185