We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical and imaging features of six Han patients with SAPHO syndrome.
- Authors
Ruan, Dan-dan; Wang, Ruo-li; Hu, Ya-nan; Lin, Xing; Luo, Jie-wei; Yu, Qing-hua; Wu, Jia-bin
- Abstract
Background: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune disease characterized by skin or osteoarticular damage. SAPHO syndrome is often misdiagnosed or missed diagnosis due to lack of overall understanding of the disease by clinicians. Purpose: To analyze the clinical symptoms and imaging features of six Han patients with SAPHO syndrome in order to provide reference for doctors to diagnose SAPHO syndrome. Material and Methods: This study retrospectively analyzed the clinical data of six Han patients with SAPHO syndrome. Results: All six Han patients with SAPHO syndrome had severe acne or pustulosis of the hands and feet, and all of them had osteoarticular damage, including five cases involving the sternoclavicular joint. Some patients showed a specific and typical "bull's head" sign on 99mTc-labeled methylene diphosphonate bone imaging. Among the six patients recruited, there was one thoracic vertebra, one cervical vertebra, one sacroiliac joint, and one peripheral joint involvement. Two patients had limited activity due to severe osteoarticular damage. Conclusion: Due to the atypical clinical symptoms of SAPHO syndrome, most patients will experience a tortuous and long diagnostic process, while a correct understanding and timely intervention of SAPHO syndrome are essential to improve the prognosis of patients.
- Subjects
DIAGNOSTIC imaging; STERNOCLAVICULAR joint; SACROILIAC joint; CERVICAL vertebrae; THORACIC vertebrae; HAND-foot syndrome
- Publication
Acta Radiologica, 2024, Vol 65, Issue 2, p211
- ISSN
0284-1851
- Publication type
Article
- DOI
10.1177/02841851221142783