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- Title
Short communication: High prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana.
- Authors
Röwer, Susanne; Bienzle, Ulrich; Weise, Alexander; Lambertz, Ulrike; Forst, Thomas; Otchwemah, Rowland N.; Pfützner, Andreas; Mockenhaupt, Frank P.
- Abstract
Recently, Ghana has changed the first-line treatment of uncomplicated malaria from chloroquine to amodiaquine (AQ) plus artesunate. AQ may cause adverse events such as agranulocytosis and hepatoxicity. The pro-drug AQ is transformed by cytochrome P450 CYP2C8 to the active metabolite N-desethylaminodiaquine. Several polymorphic variants of CYP2C8 are known, some with reduced activity. In 200 randomly selected children from Northern Ghana, we determined the allele frequencies of the CYP2C8 variants CYP2C8*1 (wild type), CYP2C8*2, CYP2C8*3, and CYP2C8*4. We did not detect CYP2C8*3 and CYP2C8*4, but CYP2C8*2 showed an allele frequency of 0.1675. AQ metabolism in patients with CYP2C8*2 may be impaired, and with an increase of AQ based treatment the risk of severe adverse events may mount.
- Subjects
GHANA; MALARIA; THERAPEUTICS; CYTOCHROME P-450; PRODRUGS; AGRANULOCYTOSIS
- Publication
Tropical Medicine & International Health, 2005, Vol 10, Issue 12, p1271
- ISSN
1360-2276
- Publication type
Article
- DOI
10.1111/j.1365-3156.2005.01525.x