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- Title
Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma.
- Authors
Gad, S.; Lefèvre, S. H.; Khoo, S. K.; Giraud, S.; Vieillefond, A.; Vasiliu, V.; Ferlicot, S.; Molinié, V.; Denoux, Y.; Thiounn, N.; Chrétien, Y.; Méjean, A.; Zerbib, M.; Benoît, G.; Hervé, J. M.; Allègre, G.; Bressac-de Paillerets, B.; Teh, B. T.; Richard, S.
- Abstract
BHD, TP53, and HNF1β on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1β mutations, (84% mutations involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.British Journal of Cancer (2007) 96, 336–340. doi:10.1038/sj.bjc.6603492 www.bjcancer.com Published online 28 November 2006
- Subjects
RENAL cell carcinoma; GENETIC mutation; GENETIC polymorphisms; RENAL cancer; TUMOR suppressor genes; METHYLATION
- Publication
British Journal of Cancer, 2007, Vol 96, Issue 2, p336
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/sj.bjc.6603492