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- Title
Cancer risks among BRCA1 and BRCA2 mutation carriers.
- Authors
Levy-Lahad, E.; Friedman, E.
- Abstract
BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.British Journal of Cancer (2007) 96, 11–15. doi:10.1038/sj.bjc.6603535 www.bjcancer.com
- Subjects
CANCER genes; BREAST cancer; OVARIAN cancer; CANCER in women; PREOPERATIVE risk factors; GENETIC load
- Publication
British Journal of Cancer, 2007, Vol 96, Issue 1, p11
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/sj.bjc.6603535