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- Title
Novel Ultrastructural Insights into the Clear-Cell Carcinoma of the Pancreas: A Case Report.
- Authors
Giansante, Valentina; Di Angelo, Luca; Calabrese, Chiara; De Sanctis, Paolo; Regi, Paolo; Martelli, Filippo Maria; Stati, Gianmarco; Lattanzio, Rossano; Alberti, Saverio; Guerra, Emanuela; Di Pietro, Roberta
- Abstract
Pancreatic cancer, most frequently as ductal adenocarcinoma (PDAC), is the third leading cause of cancer death. Clear-cell primary adenocarcinoma of the pancreas (CCCP) is a rare, aggressive, still poorly characterized subtype of PDAC. We report here a case of a 65-year-old male presenting with pancreatic neoplasia. A histochemical examination of the tumor showed large cells with clear and abundant intracytoplasmic vacuoles. The clear-cell foamy appearance was not related to the hyperproduction of mucins. Ultrastructural characterization with transmission electron microscopy revealed the massive presence of mitochondria in the clear-cell cytoplasm. The mitochondria showed disordered cristae and various degrees of loss of structural integrity. Immunohistochemistry staining for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) proved specifically negative for the clear-cell tumor. Our ultrastructural and molecular data indicate that the clear-cell nature in CCCP is linked to the accumulation of disrupted mitochondria. We propose that this may impact on the origin and progression of this PDAC subtype.
- Subjects
PANCREAS; NADH dehydrogenase; TRANSMISSION electron microscopy; CARCINOMA; BREAST; PANCREATIC cancer
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 8, p4313
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25084313