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- Title
Pain and neurodevelopmental outcomes of infants born very preterm.
- Authors
Giordano, Vito; Deindl, Philipp; Gal, Elisabeth; Unterasinger, Lukas; Fuiko, Renate; Steinbauer, Philipp; Weninger, Manfred; Berger, Angelika; Olischar, Monika
- Abstract
Aim: To investigate the impact of the level of pain experienced by infants born preterm on neurodevelopmental outcomes during their stay in a neonatal intensive care unit. Method: In this retrospective data analysis we included all surviving infants born preterm with a gestational age between 23 and 32 weeks from 2011 to 2015, who were assessed using the Neonatal Pain, Agitation, and Sedation Scale and examined at 1 year of age using the Bayley Scales of Infant Development. We excluded all infants who had suffered severe neurological morbidities and undergone surgical interventions. Results: A total of 196 infants born preterm were included in the analyses: 105 in the 'no pain group' and 91 in the 'pain group'. Significant differences between the groups were detected for both mental and motor development (p = 0.003, 95% confidence interval [CI] 2.23–10.92; p = 0.025, 95% CI 0.64–9.78). The results remained significant after controlling for other important medical conditions (p = 0.001, 95% CI −19.65 to −5.40; p = 0.010, 95% CI −16.18 to −2.29). Interpretation: Neonatal pain exposure was associated with altered neurodevelopmental outcomes of infants born very preterm at a corrected age of 12 months. This observation highlights the importance of adequate pain management to reduce the risk of poor neurodevelopmental outcomes in these vulnerable patients.
- Subjects
NEONATAL intensive care units; INFANTS; NEURAL development; NEONATAL sepsis; PREMATURE infants; INFANT development
- Publication
Developmental Medicine & Child Neurology, 2023, Vol 65, Issue 8, p1043
- ISSN
0012-1622
- Publication type
Article
- DOI
10.1111/dmcn.15505