We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies.
- Authors
Du, Wei; Gao, Yiru; Liu, Li; Sai, Sixiang; Ding, Chen
- Abstract
Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies.
- Subjects
MYCOSES; CANDIDIASIS; ECHINOCANDINS; ANTIMETABOLITES; POLYENES; AZOLES
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 18, p10104
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms221810104