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- Title
"Simple but not simpler": toward a unified picture of energy requirements in cell death.
- Authors
Chiarugi, Alberto
- Abstract
In 1996, Wang and his group empirically disclosed a key role of (deoxy)-ATP in functioning of the apoptotic machinery. After almost a decade, and despite the emerged intricacy of the death pathways, ATP is still considered a key determinant of apoptosis with no apparent active roles in necrosis. Yet recent findings indicate that apoptosis proceeds even without energy and that necrosis can be regulated by ATP-dependent processes. This review strictly focuses on current knowledge on the role of energy in execution of different death programs. A thorough understanding of energy requirements in cell death can help to overcome obsolete dogmas in cell biology, paving the way to a more integrated, albeit not simpler, view of the molecular mechanisms contributing to cell dismantling.
- Subjects
ADENOSINE triphosphate; NECROSIS; APOPTOSIS; CELL death; CYTOLOGY
- Publication
FASEB Journal, 2005, Vol 19, Issue 13, p1783
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-4200rev