We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prodrug Strategies for Paclitaxel.
- Authors
Ziyuan Meng; Quanxia Lv; Jun Lu; Houzong Yao; Xiaoqing Lv; Feng Jiang; Aiping Lu; Ge Zhang
- Abstract
Paclitaxel is an anti-tumor agent with remarkable anti-tumor activity and wide clinical uses. However, it is also faced with various challenges especially for its poor water solubility and low selectivity for the target. To overcome these disadvantages of paclitaxel, approaches using small molecule modifications and macromolecule modifications have been developed by many research groups from all over the world. In this review, we discuss the different strategies especially prodrug strategies that are currently used to make paclitaxel more effective.
- Subjects
PACLITAXEL; SMALL molecules; MACROMOLECULES; PRODRUGS; ANTIBODY-directed enzyme prodrug therapy; THERAPEUTICS
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 5, p796
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17050796