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- Title
Human Chorionic Membrane: A Novel and Efficient Alternative to Conventional Collagen Membrane.
- Authors
D'Lima, Cynthia; Samant, Urmila; Gajiwala, Astrid Lobo; Puri, Ajay
- Abstract
At the Tata Memorial Hospital (TMH) Tissue Bank while amnion was processed for clinical use, the chorion along with the placenta was routinely discarded. The quest for an efficient, natural and cost effective barrier membrane that would be suitable for guided tissue regeneration in oral surgeries, led to the processing of human chorionic membrane. The TMH Tissue Bank currently provides chorion allografts, a novel biomaterial that is routinely used in oral and periodontal surgeries in India. The TMH Tissue Bank is the first tissue bank to process and supply chorion allografts. Placentae along with the amniotic membrane were procured from screened, healthy donors after obtaining their informed written consent. The chorion layer was separated from the placenta, processed, lyophilized and sterilized by gamma irradiation at a dose of 25kGy. The TMH Tissue Bank began processing chorion in 2008. From the years 2008 to 2018, the TMH Tissue Bank produced 12,597 chorion grafts of which 11,726 chorion grafts were utilized by oral surgeons nationwide. Human chorionic membrane supplied by the TMH Tissue Bank is a natural, biocompatible, bioresorbable and non-immunogenic membrane. It has proven to be an efficacious alternative to conventional collagen membranes. During the period under study, there were no reported incidents of adverse reactions. Most tissue banks the world over process only the amnion and discard the chorion membrane, a valuable biomaterial as a biomedical waste. Processing both the amnion and chorion from the same donor also brings down the processing cost of the allografts making it more affordable thereby reducing the total cost of the surgery. The paper describes the processing, the clinical use and the many advantages of chorion allografts.
- Subjects
INDIA; GUIDED tissue regeneration; AMNION; TISSUE banks; CHORION; ORAL surgeons; COLLAGEN
- Publication
Trends in Biomaterials & Artificial Organs, 2020, Vol 34, Issue 1, p33
- ISSN
0971-1198
- Publication type
Article